By Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)
This publication, written through best authors within the box, is the 1st to accommodate all features of cytokine antibodies, from attempt technique and standardization to organic results and capabilities. It encompasses antibodies caused through cytokines used therapeutically and antiviral antibodies. to appreciate the biology, the results of cytokine antibodies in experimental animal versions and sufferers also are mentioned. The booklet is meant for researchers of cytokine biology, pharmaceutical businesses constructing cytokines and cytokine antibodies as treatments, and clinicians drawn to modulating the immune method as therapy.
Read or Download Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals PDF
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Additional info for Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals
However, antibodies are also of crucial importance in a second prominent line of defense, known as antibody-dependent cellular cytotoxicity (ADCC). This cytotoxicity is directed to cells expressing viral antigens on their surface. Although the T HI types of cells are central in cellular immunity, they are less effective than T H2 cells in providing help for Ig synthesis (57). This seems to be correlated with the ability of T HI cells to kill antigen-presenting B cells by a Fas signaling pathway (58, 59).
Inhibition of the biological activity of human interferon-')' by antipeptide antibodies. J Interferon Res 1992; 12: 49-54. Caruso A, Tiberio L, De Rango C, Bonfanti C, F1amminio G, Gribaudo G, Monti E, Viani E, Manca N, Garotta G, Landolfo S, Balsari A, Turano A. A monoclonal antibody to the NH2terminal segment of human IFN-')' selectively interferes with the antiproliferative activity of the Iymphokine. J Immunol 1993; 150: 1029-1035. Folghera S, Caruso A, Fiorentini S, Rusnati M, Gao J, Gargiulo F, Balsari A, Turano A.
To interfere in vitro with the antiviral, antiproliferative and immunomodulating activity of IPN-,. Human anti-lPN-, antibodies did not impair the antiviral and antiproliferative activity of IPN-,. However, they interfered with the immunomodulating activity ofthe Iymphokine . U937 cells incubated in a medium containing lPN-" increased the expression of HLA-DR antigens on their surface. The maximum effect was reached at 24 h, with lPN-'/' at a concentration of 200 U/ml. On the other hand, when affinitypurified human anti-lPN-'/' antibodies were present in U937 cell cultures stimulated with lPN-,/" they dramatically inhibited the expected increase in HLA-DR antigens.
Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals by Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)