New PDF release: Advances in Metabolic Mapping Techniques for Brain Imaging

By L. Sokoloff (auth.), F. Gonzalez-Lima, Th. Finkenstädt, H. Scheich (eds.)

ISBN-10: 0792319478

ISBN-13: 9780792319474

ISBN-10: 9401052026

ISBN-13: 9789401052023

ISBN-10: 9401127123

ISBN-13: 9789401127127

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Extra info for Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions

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5 JLmols to assure tracer conditions) of p4C]DG per kg of body weight, and timed arterial blood samples are drawn at sufficiently frequent intervals to define fully C;(t), the time course of the arterial plasma P4C]DG concentration. At about 45 minutes the animal is decapitated, and the brain is removed, frozen in Freon XII or isopentane maintained between 40° and -6Q°C with liquid N2 , and stored at -70°C. until sectioned and autoradiographed. The experimental period may be limited to 30 minutes but no less; this is permissible and may sometimes be necessary for experimental expediency, but greater errors due to possible inaccuracies in the rate constants may result.

2. Design of Experimental Procedure. The equation in Fig. 6B is obviously too complex to be useful. The experimental procedure was, therefore, designed to simplify the equation as well as to comply better with the assumptions made in its derivation. As with the p4C]deoxyglucose method, administration of the labeled tracer an intravenous pulse followed by a long enough experimental period for the arterial plasma p4C]leucine content (C;) to be cleared by the total body tissues and to fall to very low levels was advantageous.

6B can be reduced to the following relatively simple operational equation with which to determine Rj , the rate of leucine incorporation into any tissue i in which the concentration of label can be measured by quantitative autoradiography. Ri = --------- " 1: [7 ] IG;(')/Gp]d, The only factor in the operational equation (Equation [7]) that is not measured at the same time during the procedure for measurement of local protein synthesis is ~, which must be evaluated separately, just as is the lumped constant of the deoxyglucose method.

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Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions by L. Sokoloff (auth.), F. Gonzalez-Lima, Th. Finkenstädt, H. Scheich (eds.)


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